Testicular and paratesticular prepuberal tumors are rare. They represent around 1% of the total of tumors of infancy. They subdivide in 2 groups: germ cells tumors and non germ cells tumors, being able to occur in all the ages, and about 75% are malignant, and about 19% of these they present metastasis. The tumors of germ cells tumors represent 60 75% of the tumors testiculars in infancy, having as main example the yolk sac tumor (65% of the neoplasms), followed for teratomas (14%); although some works to exist where teratoma, if presents as most common .The non germ cells tumors include the Leydig cell tumor and Sertoli cell tumor. The Leydig cell tumor, are most frequent between the non germ cells tumors testicular. This review article on epidemiology, diagnosis and treatment of to testicular and to paratesticular tumors in child.

Zigomicoses são micoses subcutâneas causadas por fungos do solo, que geralmente manifestam-se como uma infiltração granulomatosa crônica da submucosa nasal, estendendo-se para o tecido subcutâneo e pele da face. Descreve-se aqui o primeiro caso de zigomicose nasofacial causada pelo Conidiobolus coronatus, ocorrendo em Mato Grosso, Brasil.

Zygomycosis is a subcutaneous mycosis caused by soil fungi, such as Conidiobolus coronatus. In general, the main clinical manifestation is a chronic rhinofacial tumor. We report the first case of zygomycosis (entomophthoramycosis) caused by Conidiobolus coronatus, occurring in Mato Grosso, West Brazil.

Relata-se necropsia de natimorto com hipertireoidismo congênito, filho de mãe portadora de doença de Graves não tratada, que teve como causa de óbito insuficiência cardíaca congestiva. Os achados fundamentais foram vistos no crânio, tireóide coração e placenta. As suturas cranianas encontravam-se fechadas, com acavalgamento dos ossos cranianos. A tireóide apresentava aumento de volume e congestão sangüinea intensa e, histologicamente, os folículos mostravam hiperatividade. O coração estava aumentado de volume, amolecido, com cavidades dilatadas e sufusões hemorrágicas no epicárdio. A placenta apresentava infartos que acometiam menos de 20% da superfície placentária e os vasos do cordão umbilical encontravam-se completamente expostos por diminuição da geléia de Warton. O hipertireoidismo ficou comprovado pelos dados clínicos maternos, os achados fetais de exoftalmia, craniosinostose prematura e bócio com sinais de hiperatividade folicular. A craniosinostose é causada pela ação anabólica dos hormônios tireoidianos na formação óssea, nos estágios iniciais do desenvolvimento. O início tardio do tratamento no presente caso contribuiu para severidade do hipertireoidismo fetal e óbito.

We report the autopsy of a stillborn fetus with congenital hyperthyroidism born to a mother with untreated Graves' disease, whose cause of death was congestive heart failure. The major findings concerned the skull, thyroid, heart, and placenta. The cranial sutures were closed, with overlapping skull bones. The thyroid was increased in volume and had intense blood congestion. Histological examination showed hyperactive follicles. The heart was enlarged and softened, with dilated cavities and hemorrhagic suffusions in the epicardium. The placenta had infarctions that involved at least 20% of its surface, and the vessels of the umbilical cord were fully exposed due to a decrease in Wharton 's jelly. Hyperthyroidism was confirmed by the maternal clinical data, the fetal findings of exophthalmia, craniosynostosis, and goiter with signs of follicular hyperactivity. Craniosynostosis is caused by the anabolic action of thyroid hormones in bone formation during the initial stages of development. The delayed initiation of treatment in the present case contributed to the severity of fetal hyperthyroidism and consequent fetal death.

Relata-se caso de hanseníase virchowiana diagnosticada à necropsia, com alterações cardíacas causadas diretamente por micobactérias, em homem de 34 anos portador de miocardiopatia crônica chagásica. Enfatiza-se o possível papel de mediadores inflamatórios na gênese da disfunção miocárdica; bem como a possibilidade de que fatores associados à insuficiência cardíaca, como esplenomegalia congestiva e infartos esplênicos, possam causar imunodepressão, predispondo à infecção generalizada.

This is a case report of lepromatous infection diagnosed at necropsy, with cardiac alterations directly caused by mycobacteria, in a 34-year old black male with the cardiac form of Chagas' disease. The possible role of inflammatory mediators on cardiac dysfunction, and the possibility that immunedepression may be due to factors associated with heart failure, as congestive splenomegaly and splenic infarctions, are emphasized.